• Single screening for Lynch syndrome beats sequential tests in CRC

    on March 30th, 2018
    FROM JAMA ONCOLOGY Physicians could more accurately test patients with colon cancer for Lynch syndrome by using a single tumor sequencing test instead of the current protocol of up to six sequential tests, a new study suggests. The process may also be faster in some cases. “We found that up-front [...]
  • Prior bariatric surgery may lead to IBD

    on March 30th, 2018
    FROM ALIMENTARY PHARMACOLOGY AND THERAPEUTICS Bariatric surgery increases the risk of new-onset inflammatory bowel disease (IBD), according to a case series and national database study. “A past history of bariatric surgery, but not recent surgery, was associated with both new-onset” Crohn’s di[...]
  • Survival worse with alcohol-related HCC, compared with other types

    on March 27th, 2018
    FROM CANCER Hepatocellular carcinoma (HCC) related to alcohol use tends to be diagnosed at a later stage than HCC from other causes, which contributes to reduced overall survival among patients with alcoholic HCC, investigators in a prospective French study said. Among 894 patients diagnosed with HC[...]
  • Oral SGLT-2 inhibitor reduced liver fat in diabetics with NAFLD

    on March 27th, 2018
    REPORTING FROM ENDO 2018 CHICAGO (FRONTLINE MEDICAL NEWS) – Empagliflozin, an oral sodium-glucose cotransporter 2 (SGLT-2), reduced liver fat by 5% and improved ALT in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus, according to a study presented at the annual [...]
  • MicroRNAs flag liver damage in HIV-, HCV-infected persons

    on March 27th, 2018
    REPORTING FROM CROI BOSTON (FRONTLINE MEDICAL NEWS) – In persons infected with HIV-1, with or without hepatitis C coinfections, specific circulating microRNAs may signal the presence of liver injury and progression, investigators stated. An analysis of small RNA expression in plasma samples from 1[...]
  • Switching to tenofovir alafenamide may benefit HBV patients

    on March 26th, 2018
    EXPERT ANALYSIS FROM DIGESTIVE DISEASES: NEW ADVANCES PHILADELPHIA (FRONTLINE MEDICAL NEWS) – Tenofovir alafenamide, the newest kid on the block for treatment of chronic hepatitis B, not only has less bone and renal effects than tenofovir disoproxil, but now also appears to improve those parameter[...]
  • Update on AGA-Medtronic Research & Development Pilot Award in Technology

    on March 22nd, 2018
    REPORTING FROM 2018 AGA TECH SUMMIT BOSTON – It’s been just a year since Bani Chander Roland, MD , FACG, was awarded the 2017 AGA-Medtronic Research & Development Pilot Award in Technology by the AGA Research Foundation , and her team already has recruited 30 patients with irritable bowel sy[...]
  • Maternal biologic therapy does not affect infant vaccine responses

    on March 22nd, 2018
    EXPERT ANALYSIS FROM RWCS 2018 MAUI, HAWAII (FRONTLINE MEDICAL NEWS) – The infants of inflammatory bowel disease patients on biologic therapy during pregnancy and breastfeeding do not have a diminished response rate to the inactivated vaccines routinely given during the first 6 months of life, Uma[...]
  • Putting IBD medication risks into perspective

    on March 22nd, 2018
    EXPERT ANALYSIS FROM GUILD 2018 MAUI, HAWAII (FRONTLINE MEDICAL NEWS) – Prolonged corticosteroid therapy for inflammatory bowel disease (IBD) was associated with a significantly increased mortality risk compared with anti–tumor necrosis factor therapy in a landmark study spotlighted by Edward V.[...]
  • H. pylori eradication cuts new gastric cancers by half

    on March 21st, 2018
    FROM THE NEW ENGLAND JOURNAL OF MEDICINE Treatment for Helicobacter pylori infection cut the incidence of new gastric cancers in half among patients undergoing endoscopic resection of early gastric cancer, according to results of a recent randomized, placebo-controlled study. Patients receiving H. p[...]
  • DPP-4 inhibitors increase IBD risk in diabetes

    on March 21st, 2018
    FROM THE BMJ Dipeptidyl peptidase-4 inhibitors are associated with a 75% increase in the risk of inflammatory bowel disease (IBD) in individuals with type 2 diabetes, a study has found. Researchers reported the results of an observational cohort study of 141,170 patients with type 2 diabetes newly t[...]
  • Red meat intake linked to NAFLD risk

    on March 20th, 2018
    FROM JOURNAL OF HEPATOLOGY Higher dietary intake of red meat and processed meats such as salami may increase the risk of nonalcoholic fatty liver disease and insulin resistance, new research suggests. In a cross-sectional study, published in the March 20 edition of the Journal of Hepatology , resear[...]
  • Alcohol dependence may accelerate aging, frontal cortical deficits

    on March 14th, 2018
    FROM JAMA PSYCHIATRY Alcoholism compounds age-associated volume deficits in the frontal cortex, independent of the additional effects of drug dependence or hepatitis C infection, suggests new research published March 14 in JAMA Psychiatry. Edith V. Sullivan, PhD, and her coauthors reported the resul[...]
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