Infectious diseases

  • Always get culture in symptomatic children with neurogenic bladder

    on March 30th, 2018
    FROM PEDIATRICS In the symptomatic child with neurogenic bladder at risk for urinary tract infection (UTI), urine culture should be performed regardless of the results of urinalysis, recommended Catherine S. Forster, MD , of Cincinnati Children’s Hospital Medical Center, and her associates. In a g[...]
  • QI initiative reduces antibiotic use in chorioamnionitis-exposed newborns

    on March 29th, 2018
    FROM PEDIATRICS A hospital quality improvement initiative reduced antibiotic use by more than half when well-appearing newborns exposed to chorioamnionitis were initially monitored for symptoms instead of routinely given antibiotics, found a study in Pediatrics . “The reduction in both antibiotic [...]
  • Are higher rifampin doses for pulmonary TB more effective?

    on March 29th, 2018
    REPORTING FROM CROI 2018 BOSTON (FRONTLINE MEDICAL NEWS) – Current daily doses of rifampin for treating pulmonary tuberculosis may be too low and could be safely increased, results of a randomized phase 2 study suggest. “Back in the 1970s, rifampin was an expensive drug, and attempts to shorten [...]
  • Time to HIV rebound in infants off ART linked to birth health

    on March 28th, 2018
    FROM CROI 2018 BOSTON (FRONTLINE MEDICAL NEWS) – For infants with HIV infection, baseline immune function and birth health appear to influence viral control after the discontinuation of antiretroviral therapy (ART), an analysis of data from the landmark CHER trial shows. Among 183 children diagnos[...]
  • Waning vaccine immunity linked to pertussis resurgence

    on March 28th, 2018
    FROM SCIENCE TRANSLATIONAL MEDICINE The resurgence of whooping cough in the United States could be the result of waning pertussis immunity combined with incomplete historical coverage, researchers said. In the March 28, 2018, edition of Science Translational Medicine , researchers reported on a stud[...]
  • MicroRNAs flag liver damage in HIV-, HCV-infected persons

    on March 27th, 2018
    REPORTING FROM CROI BOSTON (FRONTLINE MEDICAL NEWS) – In persons infected with HIV-1, with or without hepatitis C coinfections, specific circulating microRNAs may signal the presence of liver injury and progression, investigators stated. An analysis of small RNA expression in plasma samples from 1[...]
  • High adverse events with TB prevention in HIV-infected pregnant women

    on March 27th, 2018
    FROM CROI 2018 BOSTON – World Health Organization guidelines on the use of isoniazid to prevent tuberculosis in HIV-infected women during pregnancy may need to be reconsidered in light of new evidence that isoniazid preventive therapy (IPT) is associated with a high risk for adverse pregnancy even[...]
  • TB in 2017: Good news and bad news

    on March 27th, 2018
    FROM MMWR The rate and number of new tuberculosis cases in the United States for 2017 were the lowest since national surveillance started in 1953, but news on the TB elimination front is not so good, according to the Centers for Disease Control and Prevention. Those new lows – TB incidence of 2.8 [...]
  • Switching to tenofovir alafenamide may benefit HBV patients

    on March 26th, 2018
    EXPERT ANALYSIS FROM DIGESTIVE DISEASES: NEW ADVANCES PHILADELPHIA (FRONTLINE MEDICAL NEWS) – Tenofovir alafenamide, the newest kid on the block for treatment of chronic hepatitis B, not only has less bone and renal effects than tenofovir disoproxil, but now also appears to improve those parameter[...]
  • Efavirenz-based ART may hamper vaginal ring contraception

    on March 24th, 2018
    REPORTING FROM CROI 2018 BOSTON (FRONTLINE MEDICAL NEWS) – Efavirenz-based antiretroviral therapy may significantly impair the effectiveness of vaginal ring contraceptives, investigators reported. Over a 21-day period, levels of estrogen among women who used a vaginal ring (NuvaRing) while on efav[...]
  • RSV immunoprophylaxis in premature infants doesn’t prevent later asthma

    on March 24th, 2018
    FROM THE LANCET Respiratory syncytial virus immunoprophylaxis in premature infants does not appear to prevent asthma at age 6 years, reported Nienke M. Scheltema, MD, of Wilhelmina Children’s Hospital, Utrecht, the Netherlands, and associates. In a study of 395 otherwise healthy premature infants [...]
  • Study links mumps outbreaks to vaccine waning

    on March 23rd, 2018
    FROM SCIENCE TRANSLATIONAL MEDICINE A new study links recent mumps outbreaks to the waning of the mumps vaccine – which researchers believe wears off in an average of 27 years – and not to heterologous virus genotypes. “These observations indicate the need for either innovative clinical trial [...]
  • Low microbiota diversity linked to poor survival after transplant

    on March 22nd, 2018
    REPORTING FROM THE 2018 BMT TANDEM MEETINGS SALT LAKE CITY (FRONTLINE MEDICAL NEWS) – A multicenter study confirmed that diversity of gut microbiota is associated with better survival after allogeneic hematopoietic cell transplantation (HCT), while low diversity and the predominance of pathogenic [...]
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