Nephrology and Urology

  • HIV+ dialysis patients: Differential survival by race

    on March 21st, 2018
    FROM KIDNEY INTERNATIONAL Race, but not coinfection with hepatitis C virus, differentially affects survival of HIV-positive patients who have end-stage renal disease, according to a study published in Kidney International . Nonwhites fared significantly worse in survival than did the white cohort wh[...]
  • Emerging data help inform immunotherapy for urothelial cancer

    on March 14th, 2018
    REPORTING FROM GUCS 2018 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Emerging data from phase 3 clinical trials are better clarifying the efficacy and safety of immunotherapy in advanced urothelial cancer and helping identify patients most likely to benefit. An updated analysis of the KEYNOTE-045 tri[...]
  • Excellent prognosis for cystic RCC evaluated with radiologic threshold of greater than 50%

    on March 7th, 2018
    FROM THE JOURNAL OF UROLOGY When a standardized radiologic threshold of greater than 50% is used, patients with unifocal cystic renal cell carcinoma (cRCC) have an excellent prognosis with active surveillance and following surgical resection, findings from a new study show. At a median follow-up of [...]
  • Prostate cancer survival similar with EBRT/brachytherapy or surgery, analysts claim

    on March 2nd, 2018
    FROM JOURNAL OF CLINICAL ONCOLOGY More fuel for the radiation vs. surgery in prostate cancer debate comes from a study suggesting that patients with high-risk localized prostate cancer treated with external beam radiotherapy (EBRT) plus brachytherapy – with or without androgen deprivation (AD) –[...]
  • Bladder cancer: Two chemoradiation therapy regimens on par for muscle-invasive disease

    on February 19th, 2018
    AT THE GENITOURINARY CANCERS SYMPOSIUM SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Two concurrent chemoradiation induction regimens had similar safety and efficacy when used as part of a bladder-sparing strategy in patients with muscle-invasive bladder cancer, suggest primary results of the NRG/RTOG [...]
  • Enzalutamide shines in nonmetastatic castration-resistant prostate cancer

    on February 13th, 2018
    REPORTING FROM GUCS 2018 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – The androgen receptor inhibitor enzalutamide is efficacious for treating nonmetastatic castration-resistant prostate cancer accompanied by a rapidly rising prostate-specific antigen (PSA) level, according to results of the phase 3 P[...]
  • Sleep improved with urinary incontinence treatment

    on January 27th, 2018
    FROM OBSTETRICS & GYNECOLOGY Treating urgency urinary incontinence in women may have the added benefit of improving their quality of sleep, according to a paper published online Jan. 9 in Obstetrics & Gynecology. Researchers analyzed data from a multicenter, double-blind, randomized, control[...]
  • OS similar among mRCC patients enrolled in clinical trials across different geographic regions

    on January 16th, 2018
    FROM journal of global oncology Overall survival was similar among patients enrolled in clinical trials for metastatic renal cell carcinoma (mRCC) across different geographic regions, according to a pooled retrospective analysis. Demographic characteristics, clinicopathologic variables, survival, an[...]
  • In Brazil, few patients get second- and third-line treatment for metastatic RCC

    on January 9th, 2018
    FROM THE JOURNAL OF GLOBAL ONCOLOGY The first-line agents used for metastatic renal cell cancers in Brazil are similar to those used in fully developed countries, but many fewer patients go on to receive second- and third-line therapy, a retrospective study showed. Of 3,990 patients with metastatic [...]
  • Acute kidney injury linked with doubled inpatient VTEs

    on December 8th, 2017
    AT CHEST 2017 TORONTO (FRONTLINE MEDICAL NEWS) – Hospitalized patients with acute kidney injury had more than double the inpatient rate of venous thromboembolism as had patients without acute kidney injury in a prospective, observational study of more than 6,000 hospitalized U.S. soldiers. “I th[...]
  • Kidney transplant for GPA boosts survival

    on November 29th, 2017
    AT ACR 2017 SAN DIEGO (FRONTLINE MEDICAL NEWS) – Receiving a kidney transplant increased the likelihood of survival in patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis, a study showed. “We found that there was a huge survival advantage of having a renal transp[...]
  • FDA approves sunitinib malate as adjuvant treatment for RCC

    on November 17th, 2017
    The Food and Drug Administration has approved sunitinib malate for the adjuvant treatment of adult patients at high risk of recurrent renal cell carcinoma (RCC) following nephrectomy. “This is the first adjuvant treatment approved for patients with renal cell carcinoma, which is significant becaus[...]
  • Gut bacteria influenced response to checkpoint inhibitors

    on November 14th, 2017
    FROM SCIENCE The gut microbome may influence responses to immune checkpoint inhibitors, based on results from two studies, and one of the investigators is now gearing up for the next step – evaluating in a clinical trial whether altering the microflora will actually improve responses. In the f[...]
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