• Bacteria seen as potential lupus triggers

    on March 29th, 2018
    FROM SCIENCE TRANSLATIONAL MEDICINE A new study points to bacteria commonly found in the human microbiome as possible culprits in the quest to identify the elusive triggers of autoantibodies present in patients with systemic lupus erythematosus (SLE). Anti-Ro antibodies, including anti-Ro60 antibodi[...]
  • Cancer groups offer guidance on musculoskeletal adverse events related to checkpoint inhibitors

    on March 27th, 2018
    Recently released guidelines from two major cancer organizations have provided some of the most comprehensive guidance to date on management of musculoskeletal side effects associated with cancer immunotherapy. The guidelines, published in February, are a “sorely needed” reference point for the [...]
  • Rheumatologists push back on feds’ association health plan proposal

    on March 23rd, 2018
    A proposed rule defining association health plans has raised red flags for the American College of Rheumatology. In particular, ACR is concerned that, if enacted, the proposed rule published by the Department of Labor on Jan. 5 could create access issues. The rule as proposed would allow employers t[...]
  • Is kratom the answer to the opioid crisis?

    on March 23rd, 2018
    As the opioid epidemic continues to ravage the United States, patients and physicians are looking for less-addictive alternatives for pain control. For a growing number of U.S. patients, top among the contenders is kratom, a plant-based product that shows a dose-dependent opioidlike effect. For phys[...]
  • FDA approves IL-23 antagonist for plaque psoriasis

    on March 22nd, 2018
    The Food and Drug Administration has approved tildrakizumab, an interleukin-23 antagonist, for the treatment of moderate to severe plaque psoriasis in adults who are eligible for systemic therapy or phototherapy, according to a statement from Sun Pharma. Tildrakizumab is administered at a dose of 10[...]
  • Study links RA flares after joint replacement to disease activity, not medications

    on March 22nd, 2018
    FROM JOURNAL OF RHEUMATOLOGY Patients with the most severe cases of rheumatoid arthritis are more likely to suffer flares after knee or hip replacement surgery, a new study finds, and it doesn’t seem to matter whether they stop taking biologics before their operation. “We found that the majority[...]
  • Maternal biologic therapy does not affect infant vaccine responses

    on March 22nd, 2018
    EXPERT ANALYSIS FROM RWCS 2018 MAUI, HAWAII (FRONTLINE MEDICAL NEWS) – The infants of inflammatory bowel disease patients on biologic therapy during pregnancy and breastfeeding do not have a diminished response rate to the inactivated vaccines routinely given during the first 6 months of life, Uma[...]
  • Allopurinol dose not escalated enough to reduce mortality

    on March 21st, 2018
    FROM ARTHRITIS & RHEUMATOLOGY An allopurinol dose escalation strategy for patients with gout was associated with a small increase in all-cause mortality when compared against a static dosing strategy, results of a recent observational study show. Allopurinol dose escalation was also associated w[...]
  • Arthritis limits physical activity the most in the South

    on March 19th, 2018
    FROM MMWR SURVEILLANCE SUMMARIES “Physical activity is a proven strategy for managing arthritis symptoms,” but 35% of Americans with arthritis do not participate in any such activities or exercise, according to investigators who analyzed data from a national survey of more than 440,000 adults. A[...]
  • Febuxostat increases cardiovascular mortality in CARES trial

    on March 16th, 2018
    REPORTING FROM ACC 18 ORLANDO (FRONTLINE MEDICAL NEWS) – Long-term treatment with febuxostat in gout patients with comorbid cardiovascular disease conferred significantly higher risks of both cardiovascular death and all-cause mortality, compared with allopurinol, in the Food and Drug Administrati[...]
  • Ultrasound study supports deep Koebner mechanism in PsA pathology

    on March 15th, 2018
    FROM ANNALS OF THE RHEUMATIC DISEASES An ultrasonographic study describing the greater presence of thicker digital accessory pulleys in patients with psoriatic arthritis (PsA) than in those with only psoriatic skin disease, rheumatoid arthritis, or no pathology has lent more evidence for a “deep K[...]
  • Intramuscular steroid injection reduced hip OA pain up to 12 weeks

    on March 13th, 2018
    FROM ANNALS OF THE RHEUMATIC DISEASES Systemic treatment with an intramuscular glucocorticoid injection is effective, compared with placebo, in reducing pain in people with hip osteoarthritis for up to 12 weeks, a double-blinded, placebo-controlled, randomized trial suggests. However, the study foun[...]
  • Gut bacteria could drive autoimmune response in genetically predisposed

    on March 12th, 2018
    FROM SCIENCE Gut bacteria found in the small intestines could play a role in triggering an autoimmune response in genetically predisposed individuals, such as those with lupus, a research report suggests. Recent studies have shown that gut commensals can reside within gastrointestinal-associated lym[...]
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